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Latest Publication

Signature of genetic associations in oral cancer.

Sharma V, Nandan A, Sharma AK, Singh H, Bharadwaj M, Sinha DN, Mehrotra R.

Tumour Biol. 2017 Oct;39(10):1010428317725923.

Classically Genetics of Oral Cancer is studied at the population level following three approaches, that is, (a) candidate gene studies (CGS) which target associations between genetic variations within pre-specified genes of interest,(b) genome-wide association studies (GWAS) that, unlikely to CGS, scan the whole genome through the single-nucleotide polymorphism (SNP) array and target sequence variants with small effects, and (c) next-generation sequencing (NGS)-based studies where entire genome is deep sequenced and variants with large effects are studied. Each of these approaches identifies various genetic loci to be associated with any cancer. However, there is no available review of the literature that gives us a comprehensive knowledge of genetic loci identified to be associated with Oral Cancer by all three. This paper attempts to address this gap

Association of SNPs/haplotypes in promoter of TNF A and IL-10 gene together with life style factors in prostate cancer progression in Indian population.
Bandil K, Singhal P, Dogra A, Rawal SK, Doval DC, Varshney AK, Bharadwaj M.
Inflamm Res. 2017 Dec;66(12):1085-1097.

Is there a role of personalized cancer treatment in Prostate Cancer? According to this study, TNF A −238G>A and IL-10 −1082A>G, −819C>T and −592C>A may be associated with the development of prostate cancer and Benign Prostatic Hypertrophy. The authors also noticed higher frequency of TNF A and IL-10 risk haplotypes in smokers and alcohol users. Interestingly, IL-10 risk haplotype was positively associated with aggressiveness of tumor. This information can be used for the early diagnosis of disease and to improve tissue-specific treatment’s efficacy which will be moving ultimately towards the discovery of personalized therapy.

Stemming the Wave of Cervical Cancer: Human Papillomavirus Vaccine Introduction in India
Authors: Ravi Mehrotra, Roopa Hariprasad, Preetha Rajaraman, Rajesh Grover, Soumya Swaminathan, Vini Mahajan and Prabhdeep Kaur

Optimizing secondary prevention of cervical cancer: Recent advances and future challenges.
Authors: Ogilvie G, Nakisige C, Huh WK, Mehrotra R, Franco EL and Jeronimo J.
PMID: 28691338 

Non Communicable Disease Risk Factors and their Trends in India
Authors: Suzanne Nethan, Dhirendra Sinha and Ravi Mehrotra

Management algorithms for cervical cancer screening and precancer treatment for resource-limited settings
Authors: Basu P, Meheus F, Chami Y, Hariprasad R and Zhao F, Sankaranarayanan R.
PMID: 28691336 DOI: 10.1002/ijgo.12183

Cervical Cancer Screening in Resource-Constrained Countries: Current Status and Future Directions
Authors: Ruchika Gupta, Sanjay Gupta, Ravi Mehrotra and Pushpa Sodhani

Bacterial Vaginosis and Cervical Intraepithelial Neoplasia: Is there an Association or is Co-Existence Incidental?
Authors: Pushpa Sodhani, Sanjay Gupta, Ruchika Gupta and Ravi Mehrotra